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Effects of surgery on the acute phase response in clinically normal and diseased horses
  1. P. J. Pollock, BVMS, CertES, DipECVS, MRCVS1,
  2. M. Prendergast, MVB, PhD, CVR, CertES, MRCVS1,
  3. J. Schumacher, DVM, MVB, MS, DipACVS, MRCVS1 and
  4. C. R. Bellenger, BVSc, MVB, PhD, FACVSc, DipECVS, MRCVS1
  1. 1Department of Veterinary Surgery, Faculty of Veterinary Medicine, University College Dublin, Belfield, Dublin, Ireland

Abstract

The serum concentrations of serum amyloid A, haptoglobin and fibrinogen were measured in a group of horses before and at intervals after elective and non-elective surgery, and in a control group of normal horses. There was a significant, rapid and repeatable increase in the concentration of serum amyloid A in response to both elective and non-elective surgery. In the control horses its serum concentration was within the normal range, from 0 to 0·2 µg/ml. Twenty-four hours after elective surgery its mean peak concentration was 16·4 µg/ml, and after non-elective surgery it was 27·3 µg/ml. In contrast, the serum concentrations of haptoglobin and fibrinogen increased more slowly after surgery and had not decreased by 72 hours after surgery.

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