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Mucosal disease-like lesions in sheep infected with Border disease virus
  1. R. J. Monies, BVMS, MRCVS1,
  2. D. J. Paton, MA, VetMB, PhD, MRCVS and
  3. S. Vilcek, PhD, DSc2
  1. 1 Veterinary Laboratories Agency — Starcross, Staplake Mount, Starcross, Exeter EX6 8PE
  2. 2 Veterinary Laboratories Agency — Weybridge, New Haw,Woodham Lane, Addlestone, Surrey KT15 3NH
  1. Veterinary Laboratories Agency — Truro, Polwhele, Truro TR4 9AD
  2. Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Surrey GU24 0NF
  3. Department of Infectious and Tropical Disease, University of Veterinary Medicine, Komenskeho 73, Kosice 04181, Slovakia

Abstract

An enteric disease characterised by diarrhoea and illthrift affected 12 of a flock of 700 six- to 12-month-old ewe lambs in Cornwall between December 1996 and September 1997. The affected lambs were undersized, became thin and suffered an unremitting diarrhoea until they died. The illness lasted for three to 14 days, although, with hindsight, the owner considered that the lambs had been below average size before the enteric signs developed. The outbreak ceased only as a result of the dispersal sale of the flock as breeding ewes. The flock had been purchased from different sources, but 11 of the cases occurred in a group of 40 purchased from one source. Postmortem, the alimentary changes resembled mucosal disease in cattle, and immunostaining of histological sections of the affected tissues revealed pestiviral antigen. Non-cytopathic pestiviruses were isolated from the lesions of two of the affected lambs and from the blood of several clinically normal ewe lambs from the same group. All the pestivirus isolates were typed as Border disease virus.

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