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Effects of a single dose of dexamethasone-21 ‐ isonicotinate on the metabolism of heifers in early lactation
  1. R. Jorritsma, DVM, PhD1,
  2. J. Thanasak, DVM, PhD1,
  3. M. Houweling, DVM, PhD2,
  4. J. P. T. M. Noordhuizen, DVM, PhD1 and
  5. K. E. Müller, DVM, PhD2
  1. 1 Department of Farm Animal Health
  2. 2 Department of Biochemistry, Cell Biology and Histology, Faculty of Veterinary Medicine, Yalelaan 7, Utrecht, The Netherlands
  1. Faculty of Veterinary Science, Mahidol University, Salaya, Phuttamonthon, Nakhon-Pathom, 73170 Thailand


Eight Swedish crossbred heifers, about two-and-a-half years old, were given a single intramuscular dose of dexamethasone-21-isonicotinate between nine and 15 days after they had calved and eight similar heifers were left untreated. The treatment had no significant effects on the lipolytic activity of the heifers' fat tissues, and no effect on the concentrations of non-esterified fatty acids and β-hydroxybutyrate in blood or the triacylglycerol content of the liver. However, there were significant increases in plasma glucose concentrations two days after the injection and in plasma insulin concentrations two and four days after the injection.

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