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Urinary corticoid:creatinine ratios in healthy pet dogs after oral low-dose dexamethasone suppression tests
  1. M. M. A. R. Vaessen, DVM1,
  2. H. S. Kooistra, DVM, PhD, DipECVIM1,
  3. J. A. Mol, PhD1 and
  4. A. Rijnberk, DVM, PhD, DipECVIM1
  1. 1 Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, PO Box 80154, 3508 TD Utrecht, The Netherlands

Abstract

Eleven dogs were used in a trial to find a suitable dose of dexamethasone for an oral dexamethasone suppression test for the diagnosis of hyperadrenocorticism. Basal urinary corticoid:creatinine ratios were established in all 11 and then groups of seven were given oral doses of 0.02, 0.01 or 0.0075 mg dexamethasone/kg bodyweight and urine samples were collected at two-hour intervals from 08.00 to 22.00. The doses of 0.02 and 0.01 mg/kg consistently suppressed their urinary corticoid:creatinine ratios measured at 16.00 by a mean of more than 50 per cent and those of individual dogs to less than 1.0 x 10‐6, whereas the dose of 0.0075 mg/kg did not.

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