Veterinary Record 155:383-387 doi:10.1136/vr.155.13.383
  • Papers & Articles

Minimum inhibitory concentrations of some antimicrobial drugs against bacteria causing uterine infections in cattle

  1. A. N. Rycroft, BSc, PhD2
  1. 1 Department of Veterinary Clinical Sciences
  2. 2 Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, Hatfield AL9 7TA


The minimum inhibitory concentrations (MICs) of oxytetracycline, cephapirin, cephapirin/mecillinam, cefquinome, ceftiofur and enrofloxacin, candidate antibiotics for the principal bacteria associated with uterine infections: Escherichia coli, Arcanobacterium pyogenes and the anaerobic bacteria Fusobacterium necrophorum and Prevotella melaninogenicus, were determined by the agar dilution method. The bacteria were isolated from animals with clinical metritis and/or endometritis. For E coli, cefquinome and enrofloxacin had the lowest MIC90 and MIC50 values (<0.06 μg/ml), and oxytetracycline and cephapirin had the highest values. For A pyogenes, oxytetracycline had the highest MIC50 value (16 μg/ml), but all the cephalosporins had values below 0.06 μg/ml. For the anaerobic bacteria, enrofloxacin and oxytetracycline had the highest MIC50 values but all the cephalosporins had values of 0.06 μg/ml or below.

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