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Clinical and pathological characterisation of primary pulmonary hypertension in a dog
  1. T. M. Glaus, DrMedVet, DipACVIM, ECVIM-CA1,
  2. G. Soldati, MedVet,
  3. F. Ehrensperger, DrMedVet, DipECVP2 and
  4. R. Maurer, DrMed3
  1. 1 Division of Cardiology, Department of Small Animal Medicine
  2. 2 Department of Animal Pathology, University of Zurich, Winterthurerstrasse 260, CH-8057 Zurich, Switzerland
  3. 3 Institute of Pathology, City Hospital Triemli, CH-8057 Zurich, Switzerland

Abstract

Primary pulmonary hypertension was diagnosed in an eight-year-old labrador retriever on the basis of echocardiographic findings of severe right ventricular eccentric hypertrophy, abnormally high systolic and diastolic pulmonary arterial pressures calculated by applying the modified Bernoulli equation to the tricuspid and pulmonary insufficiency peak velocities, and the absence of any underlying disease known to cause secondary pulmonary hypertension. The clinical abnormalities developed gradually, from exercise intolerance starting early in life to terminal right-sided congestive heart failure. Consistent histopathological findings were severe intimal and medial thickening of small arteries and arterioles that led to vascular obliteration.

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