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Frequencies of prion protein (PrP) genotypes and distribution of ages in 15 scrapieaffected flocks in Great Britain
  1. S. C. Tongue, BVSc, MSc, MRCVS1,
  2. J. W. Wilesmith, BVSc, DipECVPH, HonMFPHM, MRCVS1 and
  3. C. J. Cook, BSc1
  1. 1 Scrapie Epidemiology Group, VLA — Weybridge, Woodham Lane, New Haw, Addlestone KT15 3NB


The frequencies of prion protein (PrP) genotypes were investigated in 15 scrapie-affected flocks in Great Britain. The flocks were heterogeneous in the frequencies of different genotypes and alleles, and in their age distributions. The median flock frequency of animals with VRQ-containing genotypes was 21 per cent (range 2 to 82 per cent, mean 25 per cent). The VRQ-containing and other non-ARR genotypes made up 11 to 82 per cent of a flock (median 46 per cent, mean 48 per cent). In comparison with data from the general population the scrapie-affected population had a lower frequency of the ARR/ARR genotype, and so of the ARR allele, and had a higher frequency of VRQ/non-ARR heterozygote genotypes, and thus of the VRQ allele.

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