Article Text

PDF
Cases of scrapie with unusual features in Norway and designation of a new type, Nor98
  1. S. L. Benestad, PhD1,
  2. P. Sarradin, DVM2,
  3. B. Thu, PhD1,
  4. J. Schönheit, DVM3,
  5. M. A. Tranulis, DVM, PhD4 and
  6. B. Bratberg, DVM1
  1. 1 National Veterinary Institute, Department of Pathology, Oslo, Norway
  2. 2 INRA Tours-Nouzilly, France
  3. 3 National Veterinary Institute, Bergen, Norway
  4. 4 Department of Sheep and Goat Research, Norwegian School of Veterinary Science, Sandnes, Norway
  1. Department of Biochemistry, Physiology and Nutrition, Norwegian School of Veterinary Science, Oslo, Norway

Abstract

Five cases of scrapie with unusual features have been diagnosed in Norway since 1998. The affected sheep showed neurological signs dominated by ataxia, and had the PrP genotypes homozygous A136 H154 Q171/ A136 H154 Q171 or heterozygous A136 HI54Q171/A136 R154 Q171, which are rarely associated with scrapie. Brain histopathology revealed neuropil vacuolisation essentially in the cerebellar and cerebral cortices; vacuolation was less prominent in the brainstem, and no lesions were observed at the level of the obex. The deposits of PrPSc were mainly in the cortex of the cerebellum and cerebrum, and no PrPSc was detectable by immunohistochemistry and ELISA in the lymphoid tissues investigated. Western blot analysis showed that the glycotype was different from other known scrapie strains and from the BSE strain. From a diagnostic point of view, these features indicate that this type of scrapie, designated Nor98, could have been overlooked and may be of significance for sampling in scrapie surveillance programmes.

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.