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Experimental Corynebacterium pseudotuberculosis mastitis in dairy cows
  1. I. Aroch, DVM1,
  2. A. Harmelin, BVSc1,
  3. A. Saran, DVM2,
  4. D. Levin, DVM1 and
  5. N. Y. Shpigel, BVSc, MRCVS, PhD1
  1. 1 School of Veterinary Medicine, Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel
  2. 2 Kimron Veterinary Institute, PO Box 12, Bet Dagan 50250, Israel


The inoculation of 2000 colony-forming units of Corynebacterium pseudotuberculosis into one teat canal of each of three cows resulted in severe, chronic, pyogranulomatous mastitis. Within three days the cows had a reduced haematocrit, haemoglobin concentration and red cell count. The anaemia was initially normocytic, normochromic and non-regenerative, and was associated with a brief peak of neutrophilia; a regenerative response became evident two to three weeks later. Clinical signs of mastitis appeared seven to 14 days after the inoculation, with a peak of high fever, more severe anaemia, a second peak of neutrophilia and the complete cessation of milk production from all quarters; extensive and severe pyogranulomatous mastitis developed in the inoculated quarters. No other lesions were detected postmortem, and C pseudotuberculosis was cultured from the affected quarters but not from the supramammary lymph nodes and viscera.

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