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Plasma aldosterone concentrations and plasma renin activity in healthy dogs and dogs with hyperadrenocorticism
  1. S. Javadi, DVM1,
  2. H. S. Kooistra, DVM, PhD, DipECVIM1,
  3. J. A. Mol, PhD1,
  4. P. Boer, PhD2,
  5. W. H. Boer, MD, PhD2 and
  6. A. Rijnberk, DVM, PhD, DipECVIM1
  1. 1 Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 8, PO Box 80154, NL-3508 TD Utrecht, The Netherlands
  2. 2 Department of Nephrology, University Medical Centre, Utrecht, The Netherlands

Abstract

The mean (se) basal plasma aldosterone concentrations were significantly lower in 31 dogs with pituitary-dependent hyperadrenocorticism (PDH) (75 [9] pmol/litre) than in 12 healthy dogs (118 [14] pmol/litre), whereas in five dogs with hyperadrenocorticism due to an adrenocortical tumour they were significantly higher (205 [109] pmol/litre). The mean basal renin activity was not significantly different between the dogs with PDH (303 [48] fmol/litre/second), the dogs with an adrenocortical tumour (141 [63] fmol/litre/second), and the control dogs (201 [25] fmol/litre/second). At three and four hours after the intravenous administration of 0.1 mg/kg dexamethasone, the concentrations of aldosterone decreased significantly to about 60 per cent of their initial values in the control dogs but did not change in the dogs with PDH or an adrenocortical tumour. In the dogs with PDH the renin activity increased significantly after the administration of dexamethasone.

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