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Detection of canine distemper virus antigen in canine serum and its application to diagnosis
  1. T. Soma, BVSc, MSc, PhD1,
  2. H. Ishii, BVSc, PhD2,
  3. M. Hara, BVSc, Phi3,
  4. K. Ohe, BVSc3,
  5. I. Hagimori, BVSc, PhD4,
  6. Y. Ishikawa, BVSc, PhD5 and
  7. A. Taneno, BVSc5
  1. 1 Veterinary Diagnostic Laboratory, Marupi Lifetech, 103 Fushiocho, Ikeda, Osaka 563-0011, Japan
  2. 2 Sukagawa Animal Hospital, 44-11 Morijuku, Sukagawa, Fukushima 962-0001, Japan
  3. 3 Department of Microbiology, School of Veterinary Medicine, Azabu University, 1 -17-71 Fuchinobe, Sagamihara, Kanagawa 229-8501, Japan
  4. 4 AQS, 1855-2 Komaino, Narita, Chiba 286-0121, Japan
  5. 5 Central Research Laboratories, Intervet, 1103 Fukaya, Kasumigaura, Ibaraki 300-0134, Japan


Canine distemper virus (CDV) antigen was detected in the serum of dogs by an ELISA and the results of this assay were compared with an anti-CDV immunoglobulin M (IgM) antibody test. In paired sera from 26 naturally infected dogs, the antigen-positive rate was 26.9 per cent at the first examination and 11.5 per cent at the second examination two to three weeks later. The antigen was detected in three of the 10 dogs which were negative for anti-CDV IgM antibody at the first examination. It could also be detected in the serum of between eight and two of 40 specific pathogen-free dogs vaccinated against CDV, for up to four weeks after they were vaccinated.

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