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Immunohistochemical study of the expression of E-cadherin in canine mammary tumours
  1. A. L. Reis, DVM1,
  2. J. Carvalheira, DVM, PhD2,
  3. F. C. Schmitt, MD, PhD3 and
  4. F. Gärtner, DVM, PhD1
  1. 1 Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto, Largo Prof Abel Salazar, 2, 4099-003 Porto, Portugal
  2. 2 Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares (ICETA), Universidade do Porto, Campos Agrários de Vairao, Rua do Monte- Crasto, 4485-661 Vairão, Portugal
  3. 3 Instituto de Patologia e Imunologia Molecular, Universidade do Porto, Rua Dr Roberto Frias s/n, 4200-465 Porto, Portugal


To investigate the possible role of E-cadherin in canine mammary tumours 20 benign and 40 malignant tumours were evaluated by immunohistochemistry in formalin-fixed paraffin wax-embedded samples. In all the benign tumours, E-cadherin was strongly expressed at the intercellular borders of epithelial cells, but it was less strongly expressed in 17 (43 per cent) of the malignant tumours. Furthermore, poorly differentiated carcinomas were less immunoreactive for E-cadherin than moderately and well differentiated carcinomas.

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