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Effects of anaesthesia and manual restraint on the plasma concentrations of pituitary and adrenocortical hormones in ferrets
  1. N. J. Schoemaker, DVM, DipECAMS ABVP, DipABVP1,
  2. J. A. Mol, PhD2,
  3. J. T. Lumeij, DVM, PhD, DipECAMS, DipABVP1,
  4. J. H. H. Thijssen, PhD3 and
  5. A. Rijnberk, DVM, PhD, DipECVIM2
  1. 1 Division of Avian and Exotic Animal Medicine
  2. 2 Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 8, 3584 CM Utrecht, The Netherlands
  3. 3 Department of Endocrinology, University Medical Centre Utrecht, PO Box 85090, 3508 AB Utrecht, The Netherlands

Abstract

Two experiments were carried out to investigate the effect of sampling techniques on the plasma concentrations of pituitary and adrenocortical hormones in ferrets (Mustela putorius furo). In the first experiment blood was collected on two occasions from 29 ferrets which were either manually restrained or anaesthetised with isoflurane. In the second experiment eight intact ferrets were fitted with jugular catheters and blood was collected on four occasions, just before and as soon as possible after they had been manually restrained or anaesthetised with medetomidine or isoflurane; blood was also collected 10 and 30 minutes after the induction of anaesthesia. Medetomidine anaesthesia had no effect on the plasma concentrations of pituitary and adrenocortical hormones. Isoflurane anaesthesia resulted in a significant increase in the plasma concentration of alpha-melanocyte-stimulating hormone (α-MSH) directly after the induction of anaesthesia. Manual restraint resulted in a significant increase in the plasma concentrations of cortisol and adrenocorticotrophic hormone (Acm) and a decrease in the plasma concentration of α-MSH.

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