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Influence of detomidine and buprenorphine on motor-evoked potentials in horses
  1. H. Nollet, DrMedVet1,
  2. L. Van Ham, ProfDrMedVet, PhD, DipECVN2,
  3. F. Gasthuys, ProfDrMedVet, PhD, DipECVA3,
  4. J. Dewulf, DrMedVet, MSc4,
  5. G. Vanderstraeten, ProfDrMed5 and
  6. P. Deprez, ProfDrMedvet, PhD1
  1. 1 Department of Internal Medicine and Clinical Biology of Large Animals
  2. 2 Department of Small Animal Medicine and Clinical Biology
  3. 3 Department of Surgery and Anaesthesiology of Domestic Animals
  4. 4 Department of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
  5. 5 Department of Physical Medicine and Rehabilitation, University Hospital Ghent, De Pintelaan 185, 9000 Ghent, Belgium

Abstract

Horses need to be sedated before they are investigated by transcranial magnetic stimulation because of the mild discomfort induced by the evoked muscle contraction and the noise of stimulation. This paper describes the influence of a combination of detomidine (10 μg/kg bodyweight) and a low dose of buprenorphine (2.4 μg/kg) on the onset latency and peak-to-peak amplitude of magnetic motor-evoked potentials in normal horses. There were no significant differences between measurements of these parameters made before the horses were sedated and measurements made 10 and 30 minutes after the drugs were administered.

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