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M gene evolution of canine coronavirus in naturally infected dogs
  1. A. Pratelli, DVM1,
  2. G. Elia, DVM1,
  3. V. Martella, DVM1,
  4. A. Tineili, DVM1,
  5. N. Decaro, DVM1,
  6. F. Marsilio, DVM2,
  7. C. Buonavoglia, DVM1,
  8. M. Tempesta, DVM1 and
  9. D. Buonavoglia, DVM3
  1. 1 Department of Animal Health and Wellbeing, Faculty of Veterinary Medicine, University of Bari, S.p. per Casamassima km 3, 70010 Valenzano, Italy
  2. 2 Department of Animal Pathology and Biotechnology, Faculty of Veterinary Medicine, University of Teramo, via Crucioli 122, 64100 Teramo, Italy
  3. 3 Department of Pathology and Infectious Diseases, Faculty of Veterinary Medicine, University of Messina, via S. Cecilia 30, 98123 Messina, Italy


Two stray pups (A and B), three and five months old, respectively, both naturally infeded with canine coronavirus (CCoV), were studied for 180 days. The virus was detected intermittently in the pups' faeces by PCR for periods of 156 and 146 days, respectively. Sequence analysis of a fragment of the gene encoding the M protein revealed that the viruses detected at the onset of the infection were very similar to typical strains of CCoV, whereas from 42 days after infection in pup A and 40 days after infection in pup B the viruses had nucleotide and amino acid mutations resembling sequences in feline coronavirus.

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