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Expression of mRNA of chemokine receptor CXCR4 in feline mammary adenocarcinoma
  1. S. Tanabe, DVM, PhD1,
  2. T. Nakadai, DVM1,
  3. H. Furuoka, DVM, PhD2,
  4. T. Oomachi, DVM, PhD3,
  5. Y. Kobayashi, DVM, PhD2,
  6. Y. Omata, DVM, PhD4,
  7. T. Koyama, DVM4,
  8. E. Hondo, DVM, PhD5,
  9. Y. Uzuka, DVM, PhD1,
  10. T. Sarashina, DVM, PhD1,
  11. R. J. T. Ducusin, DVM,MAgr1,
  12. T. Shida, DVM, PhD6 and
  13. M. E. Dorf, PhD7
  1. 1 Laboratory of Veterinary Internal Medicine
  2. 2 Laboratory of Veterinary Pathology
  3. 3 PATHOLAB, 7-33-12-405 Sagamidai, Sagamihara, Kanagawa 228-0821, Japan
  4. 4 Laboratory of Veterinary Physiology
  5. 5 Laboratory of Veterinary Anatomy, Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, 2-11 Inada, Obihiro, Hokkaido 080-8555, Japan
  6. 6 Department of Veterinary Radiology, Azabu University, 1-17-71 Fuchinobe, Sagamihara 229-8501, Japan
  7. 7 Department of Pathology, Harvard Medical School, Boston, MA 02115, USA

Abstract

The expression of MRNA of the chemokine receptor CXCR4 in 65 surgically resected mammary adenocarcinomas from cats was investigated by in situ hybridisation. No expression of the receptor's mRNA was detectable in the mammary tissue of healthy cats, but it was expressed in areas adjacent to necrosis, surrounding blood vessels and cells infiltrating the lymphatics of 47 (72.3 per cent) of the 65 samples. There was a significant relationship between lymphatic infiltration by neoplastic cells and the expression of the receptor's MRNA (P<0.005), but there was no significant relationship between its expression and the one-year survival of the cats.

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