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Variations in cartilage catabolism in different equine joints in response to interleukin-1 in vitro
  1. C. J. Fuller, BVSc, PhD,MRCVS1,
  2. A. R. S. Barr, MA, VetMB,PhD, CertSAO, DVR, DEO,MRCVS1 and
  3. P. A. Dieppe, BSc, MD,FRCP2
  1. 1 Division of Companion Animals, Department of Clinical Veterinary Science, University of Bristol, Langford House, Langford, Bristol BS40 7DU
  2. 2 Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR

Abstract

An explant system was used to investigate the hypothesis that cartilage from different equine joints might respond differently to challenge with interleukin-1 α (L-1 α). Pairs of normal cartilage samples were taken from the metacarpophalangeal, proximal interphalangeal and distal interphalangeal joints of six horses. One of each pair was stimulated with 10 ng/ml human recombinant IL-1 α for three days, and the supernatants and remaining cartilage explants were analysed for their total content of glycosaminoglycans. A significantly higher percentage of glycosaminoglycans was released from the cartilage of the proximal and distal interphalangeal joints than from the metacarpophalangeal joint.

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