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Evaluation and optimisation of a targetcontrolled infusion system for administering propofol to dogs as part of a total intravenous anaesthetic technique during dental surgery
  1. T. Beths, DVM, CertVA,MRCVS1,
  2. J. Reid, BVMS, PhD, DVA,DipECVA, MRCVS1,
  3. A. M. Monteiro, PhD2,
  4. A. M. Nolan, MVB, PhD,DVA, MRCVS3 and
  5. J. B. Glen, BVMS, PhD,DVA, DipECVA, MRCVS4
  1. 1 Division of Small Animal Clinical Studies
  2. 2 Departmenit of Veterinary Pharmacology
  3. 3 Department of Veterinary Preclinical Studies, University of Glasgow, 464 Bearsden Road, Bearsden, Glasgow G61 IQH
  4. 4 Zeneca Pharmaceuticals, Alderley House, Alderley Park, Macclesfield, Cheshire SK1o 4TF


The performance of a modified target-controlled infusion system was investigated in 16 dogs undergoing routine dental work, by comparing the predicted concentrations of propofol in venous blood samples with direct measurements; the optimum targets for the induction and maintenance of anaesthesia were also identified. The performance of a target-controlled infusion system is considered clinically acceptable when the median prediction error, a measure of bias, is not greater than ±10 to 20 per cent, and the median absolute performance error, a measure of the accuracy, is not greater than 20 to 30 per cent. The results fell within these limits indicating that the system performed adequately. The optimal induction target was 3 μg/ml, and anaesthesia of adequate depth and satisfactory quality was achieved with maintenance targets of between 2.5 and 4.7 μg/ml propofol. The system was easy to use and the quality of anaesthesia was adequate for dental work.

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