rss
Veterinary Record 148:172-175 doi:10.1136/vr.148.6.172
  • Papers & Articles

Acute phase protein responses to uterine bacterial contamination in caftle after calving

  1. H. Dobson, BSc, PhD, DSc3
  1. 1 Department of Farm Animal and Equine Medicine and Surgery
  2. 2 Department of Pathology and Infectious Disease, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield AL9 7TA
  3. 3 Department of Veterinary Clinical Science and Animal Husbandry, University of Liverpool, Leahurst, Neston CH64 7TE

Abstract

Repeated ultrasonographic examinations and collections of blood samples and uterine lumenal swabs between seven and 28 days after calving were used to examine the relative effects of bacterial contamination and involution of the uterus on the concentrations of acute phase proteins in the blood of 26 dairy cows. The severity of bacterial contamination, as determined by the total bacterial growth score, was a significant variable for the concentrations of the acute phase proteins α1-acid glycoprotein (P<0.0001), haptoglobin (P<0.05) and ceruloplasmin (P<0.0001). In addition, the concentrations of α1-acid glycoprotein and ceruloplasmin were increased in the cows from which Escherichia coli (P<0.0001) and Arcanobacterium pyogenes (P<0.05), respectively, were isolated from the uterine lumen. Uterine involution, as determined by the decreasing diameter of the previously gravid uterine horn, was associated with a decrease in the concentrations of α1-acid glycoprotein (P<0.005), haptoglobin (P<0.05) and ceruloplasmin (P<0.01). However, the response of the acute phase proteins to bacterial contamination was independent of the day on which the samples were collected, indicating that their concentrations were increased by bacterial contamination in addition to the changes associated with uterine involution.

    Sign up for job alerts

    Vet Record Careers features a comprehensive database of vet jobs.
    Browse for your next job, or set personalised job alerts so you hear about vacancies as soon as they go online.
    Find out more at Vet Record Careers

    Free Sample Issue

    This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of the Veterinary Record.
    View free sample issue >>

    Navigate This Article