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Comparison of in vitro activity of danofloxacin, florlenicol, oxytetracycline, spectinomycin and tilmicosin against Mycoplasma mycoides subspecies mycoides small colony type
  1. R. D. Ayling, HNC1,
  2. S. E. Baker1,
  3. R A. J. Nicholas, MSc, PhD, MIBiol1,
  4. M. L Peek, BVMS, BSc, CertVA, MRCVS2 and
  5. A. J. Simon, MA, VetMB, MRCVS2
  1. 1 Veterinary Laboratories Agency (Weybridge), New Haw, Addlestone, Surrey KT15 3NB
  2. 2 Pfizer Animal Health, Sandwich, Kent CT13 9NJ


Minimum inhibitory concentrations (Mic) and minimum mycoplasmacidal concentrations (MMc) of the antimicrobials danofloxacin, florfenicol, oxytetracycline, spedinomycin and tilmicosin were determined in vitro for 20 isolates of Mycoplasma mycoides subspecies mycoides small colony type (Mmmsc), the causative agent of contagious bovine pleuropneumonia (CBPP). The majority of strains were most susceptible to tilmicosin, followed by danofloxacin, oxytetracycline, florfenicol and spectinomycin with Mic0values of 0-015, 0-25, O-5, 1 and 8 pg/ml, and MMC50 values of 0-06, 0-5, 8, 8 and 16 pg/ml, respectively. However, tilmicosin had poor mycoplasmacidal activity against two recent strains from Portugal. There was no evidence of resistance to danofloxacin in any of the strains.

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