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Trends of antimicrobial resistance in bacterial isolates from a small animal referral hospital
  1. E. H. Normand, BVSc,CertSAM, MRCVS1,
  2. N. R. Gibson, BSc, BVMS,CertSAO, MRCVS1,
  3. S. Carmichael, BVMS,MVM, DSAO, MRCVS1,
  4. S. W. J. Reid, BVMS, PhD,MRCVS1 and
  5. D. J. Taylor, MA, VetMB,PhD, MRCVS2
  1. 1 Department of Veterinary Clinical Studies
  2. 2 Department of Veterinary Pathology, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH

Abstract

A longitudinal, retrospective investigation was made of antimicrobial resistance in bacterial isolates obtained from clinical cases in a small animal hospital between 1989 and 1997. Isolates of Escherichia coli and Staphylococcus species were used as Gram-negative and Gram-positive indicator organisms, respectively, and the annual prevalence of antimicrobial resistance was calculated for each organism to each of nine (for E coli) and 11 (for Staphylococcus species) appropriate antimicrobials, including enrofloxacin. Using a chi-square test for trend, statistically significant, rising trends were identified in the resistance of E coli to amoxycillin (P=0.04), clavulanate-amoxycillin (P<0.01) and streptomycin (P<0.01), and in the resistance of Staphylococcus species to erythromycin (P<0.01). There was an equivocal, rising trend for the resistance of Staphylococcus species to cephalexin. No significant trends were apparent for any of the other 15 organism/drug interactions. The annual prevalence of multiple drug resistance was calculated for E coli, Proteus species, Pseudomonas species, staphylococci and streptococci, but no statistically significant trends were identified.

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