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Immunohistochemical study of hormonal receptors and cell proliferation in normal canine mammary glands and spontaneous mammary tumours
  1. M. Geraldes, DVM1,
  2. F. Gärtner, DVM, PhD1 and
  3. F. Schmitt, MD, PhD1
  1. 1 Institute of Molecular Pathology and Immunology, University of Porto, Rua Dr Roberto Frias s/n, 4200 Porto, Portugal

Abstract

The expression of hormone receptors and their relationship_to cell proliferation in six samples of normal canine mammary tissue, and 11 benign and 10 malignant mammary neoplasms from female dogs were assessed by immunohistochemistry in formalin-fixed paraffin-embedded samples, by using monoclonal antibodies against progesterone and oestrogen receptors, and nuclear antigen Ki-67 (MIB-1). Malignant tumours negative for progesterone receptors proliferated at higher rates than progesterone receptorpositive tumours, suggesting that the progression towards malignancy in spontaneous mammary tumours is accompanied by a decrease in hormonal steroid dependency. Only one malignant tumour was positive for oestrogen receptors.

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