Article Text

PDF
Experimental infection of slaughter pigs with classical swine fever virus: transmission of the virus, course of the disease and antibody response
  1. H. Laevens, DVM, MSc1,
  2. F. Koenen, DVM2,
  3. H. Deluyker, DVM, PhD1 and
  4. A. de Kruif, DVM, PhD1
  1. 1 Department of Reproduction, Obstetrics and Herd Health, School of Veterinary Medicine, Salisburylaan 133, B-9820 Merelbeke, Belgium
  2. 2 Veterinary and Agrochemistry Research Center, Groeselenberg 99 B-1180 Ukkel, Belgium

Abstract

The spread of classical swine fever virus was investigated in an isolation unit containing four pens, each containing six slaughter pigs. One pig in the middle pen of three adjacent pens was inoculated intramuscularly and intranasally with the virus. The fourth pen was located in a separate compartment. containing six slaughter pigs. One pig in the middle pen of three adjacent pens was inoculated intramuscularly and intranasally with the virus. The fourth pen was located in a separate compartment. The pens were visited in a strict order to study, first, the effect of indirect contact via contaminated clothing and footwear on the spread of the virus to adjacent pens and, secondly, the airborne transmission of the virus between compartments. The pigs were examined and blood samples were taken every other day for 62 days for virological and serological analyses. The virus was highly contagious for the five pigs that were in direct contad with the inoculated pig, but spread to the other pens only after all the pigs in the originally infeded pen had become viraemic. The spread of the virus was promoted by contaminated clothing and footwear, but airbome transmission contributed considerably to the spread of the virus within the pighouse. The first clinical signs observed after the virus was introduced into a pen were decreased feed intake, increased mean rectal temperature and apathy. Neither the clinical course of the infection, nor the pattem of seroconversion observed over time, was affected by the differences in the intensity of contact with the virus between the pigs in the different pens.

    Statistics from Altmetric.com

      Request permissions

      If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.