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Bullous systemic lupus erythematosus (type I) in a dog
  1. T. Olivry, DrVet, PhD1,
  2. K C. M. Savary, DrVet1,
  3. K M. Murphy, DVM1,
  4. S. M. Dunston, BS, MS1 and
  5. M. Chen, PhD2
  1. 1 Department of Companion Animal and Special Species, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
  2. 2 Department of Dermatology, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, Illinois 60611

Abstract

In human patients with systemic lupus erythematosus, cutaneous subepidermal blistering can occur because of the production of antibodies specific for basement membrane antigens. This condition is referred to as bullous systemic lupus erythematosus (BSLE). A dog was diagnosed with BSLE because it because of the production of antibodies specific for basement membrane antigens. This condition is referred to as bullous systemic lupus erythematosus (BSLE). A dog was diagnosed with BSLE because it fulfilled the following criteria: (i) a diagnosis of systemic lupus erythematosus by standard methods; (ii) an acquired, vesicular, erosive and ulcerative eruption; (iii) microscopical subepidermal vesicles with neutrophil-predominant inflammation at the dermo-epidermal junction; (iv) deposition of IgG at the epidermal basement membrane zone; and (v) circulating IgG autoantibodies against type VIl collagen. Anti-collagen Vil type l-BSLE therefore needs to be considered as a possible differential diagnosis for canine autoimmune subepidermal blistering diseases.

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