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Pharmacokinetics of florfenicol after treatment of pigs with single oral or intramuscular doses or with medicated feed for three days
  1. J. Voorspoels, PhD1,
  2. E. D'Haese, PhD2,
  3. B. A. de craene, Pharm2,1,
  4. C. Vervaet, PhD1,
  5. D. De Riemaecker, VetDr3,
  6. P. Deprez, PhD, VetDr3,
  7. H. Nelis, PhD2 and
  8. J. P. Remon, PhD1
  1. 1 Laboratory of Pharmaceutical Technology
  2. 2 Laboratory of Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, University of Gent, Harelbekestraat 72, B-9000 Gent, Belgium
  3. 3 Department of Large Animal Medicine, Faculty of Veterinary Medicine, University of Gent, Salisburylaan 133, B-9820 Merelbeke, Belgium
  1. Laboratory of Pharmaceutical Technology

Abstract

The pharmacokinetics of florfenicol, a structural analogue of thiamphenicol, were studied in six pigs after single oral and intramuscular doses of 15 mg/kg bodyweight, and after feeding them with medicated feed containing 250 mg/kg for three days, a concentration which provided approximately the same dose rate of the drug. The oral doses contained a specially prepared pelleted formulation of the drug. The bioavailability of the drug was similar for the oral and intramuscular doses. Florfenicol was absorbed rapidly from the feed and its concentration in plasma remained between 2 and 6 μg/ml - above the minimum inhibitory concentration values for common pig pathogens - during the three days.

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      Footnotes

      • Mr de craene's present address is Micromass BV, Bedrijvencentrum Vilvoorde, Mechelsesteenweg 277 bus 9, B-1800 Vilvoorde, Belgium Mechelsesteenweg 277 bus 9, B-1800 Vilvoorde, Belgium

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