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Clindamycin hydrochloride and clavulanate-amoxycillin in the treatment of canine superficial pyoderma
  1. D. Littlewood, MA, PhD, BVSc, DVR, CertSAD, MRCVS1,
  2. K. H. Lakhani, Bar-at-Law, BSc, CStat2,
  3. S. Paterson, MA, VetMB, DVD, DipECVD, MRCVS3,
  4. J. L. N. Wood, BSc, BVetMed, MSc, PhD, MRCVS2 and
  5. N. Chanter, BSc, PhD2
  1. 1 Centre for Small Animal Studies
  2. 2 Centre for Preventive Medicine, Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU
  3. 3 Animal Medical Centre, 511 Wilbraham Road, Chorlton-cum-Hardy, Manchester M21 I UF


A masked, randomised, controlled clinical trial for the treatment of canine superficial pyoderma was undertaken. Dogs with a clinical diagnosis of superficial pyoderma, supported by bacterial culture were admitted to the trial and randomly assigned to treatment with either clindamycin hydrochloride at 5.5 mg/kg twice daily or clavulanate-amoxycillin at 12.5 mg/kg twice daily. After 21 days the animals were re-assessed, and therapy was continued for a further 21 days in the dogs with persistent lesions if bacterial culture demonstrated continued sensitivity. Twenty-nine dogs were treated with clindamycin hydrochloride and 27 with clavulanate-amoxycillin. Complete cure was obtained after three weeks in 17 (59 per cent) of the clindamycin-treated cases, but in only eight (30 per cent) of the clavulanate-amoxycillin treated group. Clindamycin was significantly more effective than clavulanate-amoxycillin for the treatment of superficial pyoderma in dogs.

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