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Malignant schwannoma in a red deer (Cervus elaphus)
  1. J. Pérez, DVM, PhD1,
  2. J. Martín de las Mulas, DVM, PhD1,
  3. A. Arenas, DVM, PhD2,
  4. I. Luque, DVM, PhD2 and
  5. L. Carrasco, DVM, PhD1
  1. 1 Departamento de Anatomía y Anatomía Patalógica Comparadas
  2. 2 Departmento de Sanidad Animal (Cátedra de Enfermedades Infecciosas), Facultad de Veterinaria, Córdoba, Spain

Abstract

A five-year-old female red deer (Cervus elaphus) was in poor condition and severely lame on the left hindleg owing to a 19.4 cm x 15.9 cm mass involving and destroying the distal end (head) of metatarsal bones III and IV, the proximal sesamoid bones and the first phalanges (III and IV). The histopathological analysis revealed a spindle cell tumour with frequent palisade arrangement (Antoni type A pattern), and with highly anaplastic tumour cells in some areas. Structures resembling peripheral nerves were identified within the tumour. The neoplastic cells reacted with vimentin in a cytoplasmic pattern, and almost all of them reacted with S-100 protein in a nuclear and cytoplasmic pattern and did not express neurofilament, glial fibrillary acidic protein or keratins. This immunophenotype and the histopathological features were consistent with a diagnostic of malignant schwannoma. It was atypical because of the species affected, the location and the local malignancy.

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