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Humoral and cell-mediated responses to Malassezia pachydermatis in healthy dogs and dogs with Malassezia dermatitis
  1. R. Bond, BVMS, PhD, DVD, DipECVD, MRCVS1,
  2. C. M. Elwood, MA, VetMB, MSc, CertSAC, DipACVIM, DipECVIM-CA, MRCVS1,
  3. R. M. Littler, MA, VetMB, CertSAM, MRCVS1,
  4. L. Pinter, DVM, PhD2 and
  5. D. H. Lloyd, BVetMed, PhD, DipECVD, FRCVS1
  1. 1 Department of Small Animal Medicine and Surgery, Royal Veterinary College, University of London, Hawkshead Campus, North Mymms, Hatfield AL9 7TA
  2. 2 Department of Microbiology and Infectious Diseases, Veterinary Faculty, University of Zagreb, PO Box 190, 10,000 Zagreb, Croatia


The in vitro proliferative responses of peripheral blood mononuclear cells from seven healthy basset hounds exposed to Malassezia pachydermatis antigen (500 μg/ml) exceeded (P<0.05) those of seborrhoeic basset hounds with high populations of M pachydermatis and eight Irish setters with glutensensitive enteropathy. The stimulation indices in the latter two groups and in eight healthy beagles were comparable. The stimulation indices of the four groups after exposure to phytohaemaglutinin did not differ significantly. The serum titres of M pachydermatis-specific IgG and IgA measured by enzymelinked immunosorbent assays (ELISA) in 21 seborrhoeic basset hounds and 11 affected dogs of various breeds exceeded those of 14 healthy basset hounds and eight healthy beagles (P<0.01 for IgG, P<0.05 for IgA). Total serum IgA concentrations measured by ELISA in the affected dogs were not lower than those of healthy dogs.

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