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A syndrome of anaemia, immunodeficiency and peripheral ganglionopathy in Fell pony foals
  1. S. F. E. Scholes, BVM&S, PhD, MRCVS, MRCPath1,
  2. A. Holliman, BVSc, BA, MSc, MRCVS2,
  3. P. D. F. May, BVMS, MRCVS3 and
  4. M. A. Holmes, MA, VetMB, PhD, MRCVS4
  1. 1 CVL Lasswade Veterinary Laboratory, Bush Estate, Penicuik, Midlothian EH26 OSA
  2. 2 Veterinary Investigation Centre, Merrythought, Calthwaite, Penrith, Cumbria CAll 9RR
  3. 3 Rowcliffe House Veterinary Hospital, Crown Square, Penrith, Cumbria CA 1I 8BG
  4. 4 University of Cambridge Department of Clinical Veterinary Medicine, Madingley Road, Cambridge CB3 OES

Abstract

Fell pony foals developed a syndrome of anaemia, immunodeficiency and peripheral ganglionopathy. They became ill in the second or third week, and died in the second or third month of life. Clinical and pathological investigations revealed severe anaemia associated with small numbers of late erythroid precursors in bone marrow, small thymi, an absence of secondary lymphoid follicles, a lack of plasma cells and neuronal chromatolysis involving trigeminal, cranial mesenteric and dorsal root ganglia. Some of the foals had cryptosporidial enteritis and adenoviral bronchopneumonia and pancreatitis. The clinical and pathological findings were compatible with an intrinsic defect.

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