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Pharmaceutical quality of anthelmintics sold in Kenya
  1. A. M. Monteiro, BSc, MSc, PhD1,
  2. S. W. Wanyangu, BVM, MSc, PhD2,
  3. D. P. Kariuki, BVSc, MSc2,
  4. R. Bain, BSc, PhD1,
  5. F. Jackson, BSc, PhD3 and
  6. Q. A. McKellar, BVMS, PhD, MRCVS3
  1. 1 Department of Veterinary Pharmacology, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH
  2. 2 National Veterinary Research Centre, Kenyan Agriculture Research Institute, Mguga, Box 32 Kikuyu, Kenya
  3. 3 Moredun Research Institute, 408 Gilmerton Road, Edinburgh EH17 7JH

Abstract

Nine anthelmintic products purchased in pharmacies and from agricultural merchants in Kenya were tested for pharmaceutical quality. The concentration of active drug was compared with the claim on the label, and the variability of several products was tested between batches and between bottles within the same batch. All the products purchased claimed to contain levamisole but its mean (sd) concentration varied from 0 to 118.0 (13.3) per cent of that claimed. The concentration of levamisole in different batches of the same product ranged from 0 to 85.4 per cent of that claimed. One product consisting in part of mebendazole was found to contain 73.2 (9.4) per cent of the claimed concentration of this active component and two products consisting in part of oxyclozanide were found to contain 106.0 (14.4) and 120.6 (6.1) per cent of the expected concentration of oxyclozanide.

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