Veterinary Record 142:392-396 doi:10.1136/vr.142.15.392
  • Papers and Articles

Activation of extracellular matrix metalloproteinases in equine laminitis

  1. N. T. Messer, DVM1
  1. 1 Department of Veterinary Medicine and Surgery
  2. 2 Department of Veterinary Biomedical Sciences
  3. 3 Department of Veterinary Pathobiology
  4. 4 Department of Intemnal Medicine, University of Missouri-Columbia, Columbia, Missouri 65211, USA


Samples of connective tissue obtained from the hoof of six laminitic and eight non-laminitic adult horses were analysed zymographically to investigate whether connective tissue matrix metalloproteinases are activated or induced during laminitis. The activity of matrix metalloproteinases was substantially greater in the tissues from the laminitic horses than in the tissues from the non-laminitic horses. A comparison of the collagenolytic activity in the laminitic and control tissues showed that collagenolytic activities corresponding to the 92 kDa (P<0.001), 72 kDa (P<0.01) and 66 kDa (P<0.01) bands were induced in the laminitic tissues.


  • Dr Tyagi's present address is Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, Mississippi 39216-4505, USA

    Sign up for job alerts

    Vet Record Careers features a comprehensive database of vet jobs.
    Browse for your next job, or set personalised job alerts so you hear about vacancies as soon as they go online.
    Find out more at Vet Record Careers

    Free Sample Issue

    This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of the Veterinary Record.
    View free sample issue >>

    Navigate This Article