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DNA marker C04107 for copper toxicosis in a population of Bedlington terriers in the United Kingdom
  1. N. G. Holmes, BSc, PhD1,
  2. M. E. Herrtage, MA, BVSc, DVR, DVD, DSAM, MRCVS2,
  3. E. J. Ryder, BSc1 and
  4. M. M. Binns, BSc, PhD1
  1. 1 Centre for Preventive Medicine, Animal Health Trust, PO Box 5, Newmarket, Suffolk CB8 7DW
  2. 2 Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES

Abstract

The DNA microsatellite marker C04107, linked to the Bedlington terrier copper toxicosis locus, is used diagnostically in the USA to detect the disease allele. This marker has been typed in Bedlington terriers of known disease status in the United Kingdom, and it is concluded that it should be useful in eradicating the disease from the breed in the UK. The marker also identified a dog which had been diagnosed on the basis of a liver biopsy as having the disease, as being unaffected; a second liver biopsy confirmed that the dog did not have copper toxicosis.

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