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Treatment of a dog with an insulinoma-related peripheral polyneuropathy with corticosteroids
  1. L. Van Ham, DVM, PhD1,
  2. K. G. Braund, DVM, BVSc, MVSc, PhD, FRCVS4,
  3. S. Roels, DVM2 and
  4. I. Putcuyps, DVM3
  1. 1 Department of Small Animal Medicine and Clinical Biology
  2. 2 Department of Veterinary Pathology
  3. 3 Department of Medical Imaging, University of Gent, Salisburylaan 133, B-9820 Merelbeke, Belgium
  4. 4 Neuromuscular Diagnostic Laboratory, Scott-Ritchey Research Center, College of Veterinary Medicine, Auburn University, Alabama 36849-5525, USA


A crossbreed dog with a history of a chronic progressive tetra-paresis had an insulinoma-related peripheral polyneuropathy. Frequent feeding and treatment with corticosteroids resulted in recovery from a non-ambulatory to an almost completely normal clinical state, despite the persistence of hypoglycaemia and hyperinsulinism. After euthanasia for uncontrollable seizures, the presence of a beta-cell carcinoma of the pancreas and extensive axonal degeneration of the peripheral nerves was confirmed by histopathological examination. These findings may indicate an immune-mediated pathogenesis for insulinoma-related peripheral polyneuropathy.

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