Article Text

PDF
Antithrombin-III activity in plasma of healthy and sick cattle
  1. N. Pusterla, DrMedVet1,
  2. U. Braun, DrMedVet1,
  3. R. Forrer2 and
  4. H. Lutz, DrMedVet2
  1. 1 Clinic of Internal Medicine of Ruminants and Horses
  2. 2 Clinical Laboratory, Department of Internal Veterinary Medicine, School of Veterinary Medicine, University of Zürich, Winterthurerstrasse 260, CH-8057 Zürich, Switzerland

Abstract

Antithrombin-III (AT-III) activity was determined in the plasma of 32 healthy cows. The range of activities was between 105 and 160 per cent of a human reference plasma; the median activity was 132.5 per cent, and the 5 per cent and the 95 per cent quartiles were 111.1 per cent and 153.9 per cent of the standard. The activity of AT-III was also determined in 82 cows with a variety of internal diseases. In cows with hepatopathy, acute enteritis, generalised peritonitis, blood loss, idiopathic cardiomyopathy, glomerulonephritis and disseminated coagulopathy, the activity of AT-III was lower than in healthy animals. The lower values were due to decreased synthesis, increased consumption, or the loss of AT-III. An acquired deficiency of AT-III appears to favour the development of thrombophlebitis.

    Statistics from Altmetric.com

      Request permissions

      If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.