Forty-four of a flock of 117 angora goats in the Rio Negro province of Argentina died within four days. Most of the animals died shortly after the onset of clinical signs, but in a few the clinical course lasted for several days. Post mortem the small and large intestines were filled with watery contents, blood and fibrin clots, and there were numerous ulcers on the mucosa. Small areas of malacia were observed histologically in the brain. Clostridium perfringens type D in pure culture was isolated from the kidneys and gut contents of the affected animals. Epsilon toxin was identified by the mouse seroneutralisation test in the supernatant solution from cultures of these isolates and in the intestinal contents of the affected animals. Heavy infestations with coccidia, nutritional and environmental stress, and an anthelmintic overdose were possible predisposing factors for the outbreak.