Article Text

Induction of virus-producing tumours in athymic nude mice by bovine papillomavirus type 4
  1. J Gaukroger,
  2. A Bradley,
  3. B O'Neil,
  4. K Smith,
  5. S Campo and
  6. W Jarrett
  1. Department of Veterinary Pathology, University of Glasgow Veterinary School, Bearsden.

Abstract

Bovine papillomavirus type 4 (BPV-4), the causative agent of alimentary papillomatosis, has been used to infect, in vitro, fragments of palatine mucosa from late term bovine fetuses. These small explants were placed beneath the renal capsule of athymic nude mice where they grew to produce, at first, squamous epithelial cysts containing BPV-4 genomic DNA and, later, papillomas which were morphologically identical to those of cattle and which contained large amounts of replicating virus. The possible utility of this technique in assessing neutralising antibodies in vaccine development is discussed.

    Statistics from Altmetric.com

      Request permissions

      If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.