Tiamulin was found to be effective in the treatment of experimental swine dysentery when included in the drinking water at 22.5, 45 and 60 ppm for three and five days. Only medication of the drinking water with 60 ppm for three and five days resulted in complete prevention of relapse and the elimination of T hyodysenteriae. When tiamulin was given in the feed for 47 days at 25, 30, 35 and 40 g per ton it prevented the development of the clinical signs or post mortem lesions of experimental swine dysentery. The results obtained suggested that it may not have completely prevented the establishment of T hyodysenteriae in the intestines of some of the pigs. The possibility that tiamulin had some effect on the lesions of enzootic pneumonia when given in the drinking water at 60 ppm and in the feed at 40 g per ton is discussed.
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