The re-excretion of feline viral rhinotracheitis (FVR) virus (feline herpesvirus I) by FVR-recovered cats is recorded both spontaneously and following a variety of stimuli, namely, corticosteroid administration, change of housing, and parturition and lactation. At least 27 of 33 (82%) FVR-recovered cats studied were shown to be viral carriers. The carrier state was characterised by periods of viral latency interspersed with episodes of viral shedding. Administration of 0-75 mg dexamethasone trimethylacetate and 2-25 mg prednisolone on days 0,2 and 4 resulted in re-excretion after a mean lag period of 7-2 days in 22 of 32 (69%) FVR-recovered cats on a total of 31 of 57 (54%) occasions. Rehousing resulted in virus re-excretion after a mean lag period of 7-2 days in four of 22 (18%) cats tested on a total of six of 40 (15%) occasions. Apparently spontaneous shedding occurred on a total of 10 occasions in nine of 31 (29%) cats during a mean observation period of 8-8 months. Four of six FVR-recovered queens in a total of four of 10 litters (40%) shed virus within two to 10 weeks of parturition. Serum neutralising antibody titres were generally boosted at the time of first re-infection but afterwards remained essentially constant. Although 82% of cats in these studies were shown to be viral carriers, only 45% of cats shed virus spontaneously or as a result of the natural stress situations and it is postulted that these naturally excreting cats are of most significance epidemiologically.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.